Abnehmen ist richtig mühsam. Dabei können Inkretin-Mimetika sehr wirksam helfen und sind zudem besser verträglich als Amphetamine. 1 Das neue Inkretin-Mimetikum Exenatide (Byetta®) wird zur Behandlung des TypDiabetes Zusammensetzung: Eine Fertigspritze mit /40 µl. 2 Tirzepatid (Handelsname Mounjaro) ist ein duales Inkretinmimetikum (ein GIP/GLPRezeptoragonist) zur Behandlung eines Diabetes (Typ 2). 3 Der Wirkstoff Semaglutid, der per Spritze verabreicht wird, macht Adipositas-Betroffenen nun Hoffnung. 4 Sodium-glucose transporter 2 (SGLT2) inhibitors. Medications. Canagliflozin (Invokana) Dapagliflozin (Farxiga) Empagliflozin (Jardiance) Ertugliflozin (Steglatro) Action. Limit the kidneys' ability to take in sugar, which increases the amount of sugar that leaves the body in urine. Advantages. 5 Incretin mimetics are a relatively new group of injectable drugs for treatment of type 2 diabetes The drugs, also commonly known as glucagon-like peptide 1 (GLP-1) receptor agonists or GLP-1 analogues, are normally prescribed for patients who have not been able to control their condition with tablet medication. Drugs in this class In the UK, [ ]. 6 Definition (NCI) A long-acting, fatty acylated glucagon-like peptide-1 (GLP-1) analog administered subcutaneously, with antihyperglycemic activity. Liraglutide's prolonged action and half-life of hours are attributed to the attachment of the fatty acid palmitic acid to GLP-1 that reversibly binds to albumin. 7 Although producing less weight loss, only dulaglutide has effectiveness in the primary and secondary prevention of cardiovascular disease. Semaglutide is the only orally available incretin mimetic; however, the oral formulation produces less weight loss versus its subcutaneous alternative and did not have cardioprotection in its outcomes trial. 8 Incretin mimetic drugs work in two significant ways: Increase the production of insulin. Insulin is a hormone produced by the pancreas that helps the body’s cells take up glucose (blood sugar) to use for energy. Suppress glucagon secretion. Glucagon is another hormone released by the pancreas. 9 Fortunately, new treatment modalities are in various stages of development. These will be reviewed with a more in-depth exploration of the potential of incretin mimetics, a new biologic, injectable class of drugs for the treatment of type 2 diabetes. Emphasis will be given to exenatide, an incretin mimetic that demonstrates particular efficacy. inkretinmimetika rezeptfrei 10 inkretin-mimetika 12